Impact of traumatic brain injury on amyotrophic lateral sclerosis: from bedside to bench

CK Franz, D Joshi, EL Daley… - Journal of …, 2019 - journals.physiology.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative … Patients with amyotrophic
lateral sclerosis (ALS) may have a … Current treatments only have a small effect on progression, …

[HTML][HTML] From bedside to bench-in vivo and in vitro evaluation of mechanically assisted cough treatment in a patient with bulbar amyotrophic lateral sclerosis

T Andersen, O Fondenes, OD Røksund… - Respiratory Medicine …, 2022 - Elsevier
… with Amyotrophic Lateral Sclerosis, the … Amyotrophic Lateral Sclerosis experienced that
treatment with MI-E was exhausting and inefficient. Despite adjustments of settings, all treatment

Advances, challenges, and perspectives in translational stem cell therapy for amyotrophic lateral sclerosis

E Abati, N Bresolin, G Comi, S Corti - Molecular Neurobiology, 2019 - Springer
… Moving stem cells research from bench to bedside requires a thorough knowledge of
their … of unproven treatments to patients outside clinical trial and drug agencies’ approval [43]. …

Amyotrophic lateral sclerosis: current therapeutic perspectives

V Kumar, T Kashav, MI Hassan - Pathology, prevention and therapeutics …, 2019 - Springer
… in the non-pharmacological therapy trials in ALS. Currently, no therapeutic effort seems to
be … , but recent findings in ALS will certainly help in the discovery of an effective treatment. …

Stem cell treatments for amyotrophic lateral sclerosis: a critical overview of early phase trials

SA Goutman, MG Savelieff, SA Sakowski… - … investigational drugs, 2019 - Taylor & Francis
… cell therapy for ALS holds great promise. Throughout its development from bench to bedside,
… and patients’ safety, advocating good clinical trial design to truly assess treatment efficacy. …

[HTML][HTML] A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?

X Xu, D Shen, Y Gao, Q Zhou, Y Ni, H Meng… - Translational …, 2021 - Springer
treatment of spasticity in ALS patients, as they can control spasticity with safety and efficacy
in multiple sclerosis [58… cohort study has revealed high treatment satisfaction with nabiximols, …

Therapeutic approaches to amyotrophic lateral sclerosis from the lab to the clinic

VP Chavda, C Patel, D Modh, YN Ertas… - Current Drug …, 2022 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects adults and
… from bench to bedside in the field of ALS treatment. More than 160 drug candidates or ther…

[HTML][HTML] Translational study for amyotrophic lateral sclerosis treatment

S Schröder, G Litscher, W Pan - Frontiers in Neurology, 2023 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive
loss of upper and lower motor neurons. Despite significant scientific efforts in the last …

[HTML][HTML] Inosine in neurodegenerative diseases: From the bench to the bedside

MS Basile, P Bramanti, E Mazzon - Molecules, 2022 - mdpi.com
… its safety and efficacy and its use as a complementary therapy along with other approved
drugs. … Urate levels predict survival in amyotrophic lateral sclerosis: Analysis of the expanded …

[HTML][HTML] Neuroimaging findings in preclinical amyotrophic lateral sclerosis models—How well do they mimic the clinical phenotype? A systematic review

AE Cannon, WE Zürrer, C Zejlon, Z Kulcsar… - Frontiers in Veterinary …, 2023 - frontiersin.org
… This opposes the high attrition of drugs during bench-to-bedside translation … drug development.
These findings emphasize a careful application of these model systems for ALS therapy